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Protein Z-related protease inhibitor : ウィキペディア英語版 | Protein Z-related protease inhibitor
Protein Z-dependent protease inhibitor is a protein circulating in the blood which inhibits factors Xa and XIa of the coagulation cascade. It is a member of the class of the serine protease inhibitors (serpins). Its name implies that it requires protein Z, another circulating protein, to function properly, but this only applies to its inhibition of factor X. It is about 72 kDa heavy and 444 amino acids large. It is produced by the liver. ==Role in disease== Water ''et al.'' found deficiency of ZPI in 4.4% of a cohort of patients with thrombophilia (a tendency to thrombosis).〔Water N, Tan T, Ashton F, O'grady A, Day T, Browett P, Ockelford P, Harper P. ''Mutations within the protein Z-dependent protease inhibitor gene are associated with venous thromboembolic disease: a new form of thrombophilia.'' Br J Haematol 2004;127:190-4. PMID 15461625.〕
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